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Cohesin subunits, STAG1 and STAG2, and cohesin regulatory factor, PDS5b, in oral squamous cells carcinomas.
França JA, Diniz MG, Bernardes VF, Costa-Silva RC, Souza RP, Gomez RS, Gomes CC. França JA, et al. J Oral Pathol Med. 2017 Mar;46(3):188-193. doi: 10.1111/jop.12474. Epub 2016 Jun 24. J Oral Pathol Med. 2017. PMID: 27341316
Differences between transcriptional levels of STAG1, STAG2, and PDS5B between OSCC and normal oral mucosa (NM) were evaluated by qPCR. ...CONCLUSIONS: There is LOH at STAG1 and STAG2 loci in OSCC, but OSCC and NM showed similar transcriptional levels of STAG1 …
Differences between transcriptional levels of STAG1, STAG2, and PDS5B between OSCC and normal oral mucosa (NM) were evaluated …
PDS5A and PDS5B differentially affect gene expression without altering cohesin localization across the genome.
Arruda NL, Bryan AF, Dowen JM. Arruda NL, et al. Epigenetics Chromatin. 2022 Aug 19;15(1):30. doi: 10.1186/s13072-022-00463-6. Epigenetics Chromatin. 2022. PMID: 35986423 Free PMC article.
The roles of the two mutually exclusive HEAT repeat subunits PDS5A and PDS5B are not well understood. RESULTS: Here, we determine that PDS5A and PDS5B have highly similar localization patterns across the mouse embryonic stem cell (mESC) genome and they show a strong …
The roles of the two mutually exclusive HEAT repeat subunits PDS5A and PDS5B are not well understood. RESULTS: Here, we determine tha …
Intact Cohesion, Anaphase, and Chromosome Segregation in Human Cells Harboring Tumor-Derived Mutations in STAG2.
Kim JS, He X, Orr B, Wutz G, Hill V, Peters JM, Compton DA, Waldman T. Kim JS, et al. PLoS Genet. 2016 Feb 12;12(2):e1005865. doi: 10.1371/journal.pgen.1005865. eCollection 2016 Feb. PLoS Genet. 2016. PMID: 26871722 Free PMC article.
In an effort to provide insight into these discrepancies, here we analyze the effect of tumor-derived STAG2 mutations on the protein composition of cohesin and the expected mitotic phenotypes of STAG2 mutation. We find that many mutant STAG2 proteins retain t …
In an effort to provide insight into these discrepancies, here we analyze the effect of tumor-derived STAG2 mutations on the protein …
Prognostic Values and Underlying Regulatory Network of Cohesin Subunits in Esophageal Carcinoma.
Gan W, Wang W, Li T, Zhang R, Hou Y, Lv S, Zeng Z, Yan Z, Yang M. Gan W, et al. J Cancer. 2022 Mar 6;13(5):1588-1602. doi: 10.7150/jca.66949. eCollection 2022. J Cancer. 2022. PMID: 35371307 Free PMC article.
Results: Transcriptome data from multiple ESCA patient datasets showed cohesin subunits SMC1A, SMC1B, SMC3, STAG1, STAG2, RAD21, and cohesin regulators including ESCO2, NIPBL, MAU2, WAPL, PDS5A and PDS5B were all upregulated in ESCA tissues compared to normal tissue …
Results: Transcriptome data from multiple ESCA patient datasets showed cohesin subunits SMC1A, SMC1B, SMC3, STAG1, STAG2, RAD21, and …
Optical Genome Mapping Identifies Novel Recurrent Structural Alterations in Childhood ETV6::RUNX1+ and High Hyperdiploid Acute Lymphoblastic Leukemia.
Brandes D, Yasin L, Nebral K, Ebler J, Schinnerl D, Picard D, Bergmann AK, Alam J, Köhrer S, Haas OA, Attarbaschi A, Marschall T, Stanulla M, Borkhardt A, Brozou T, Fischer U, Wagener R. Brandes D, et al. Hemasphere. 2023 Jul 17;7(8):e925. doi: 10.1097/HS9.0000000000000925. eCollection 2023 Aug. Hemasphere. 2023. PMID: 37469802 Free PMC article.
Besides SVs in known leukemia development genes (ETV6, PAX5, BTG1, CDKN2A), we identified 19 novel recurrently altered regions (in n 3) including 9p21.3 (FOCAD/HACD4), 8p11.21 (IKBKB), 1p34.3 (ZMYM1), 4q24 (MANBA), 8p23.1 (MSRA), and 10p14 (SFMBT2), as well as ETV6::RUNX1+ subtyp …
Besides SVs in known leukemia development genes (ETV6, PAX5, BTG1, CDKN2A), we identified 19 novel recurrently altered regions (in n 3) incl …
Contribution of variant subunits and associated factors to genome-wide distribution and dynamics of cohesin.
Cuadrado A, Giménez-Llorente D, De Koninck M, Ruiz-Torres M, Kojic A, Rodríguez-Corsino M, Losada A. Cuadrado A, et al. Epigenetics Chromatin. 2022 Nov 24;15(1):37. doi: 10.1186/s13072-022-00469-0. Epigenetics Chromatin. 2022. PMID: 36424654 Free PMC article.
There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of the regulatory subunit PDS5, PDS5A and PDS5B. ...We observe that both PDS5A and PDS5B are exclusively located at cohesin-CTCF posit …
There are two different cohesin complexes in vertebrate somatic cells, carrying the STAG1 or STAG2 subunit, and two versions of the r …
Low tolerance for transcriptional variation at cohesin genes is accompanied by functional links to disease-relevant pathways.
Schierding W, Horsfield JA, O'Sullivan JM. Schierding W, et al. J Med Genet. 2021 Aug;58(8):534-542. doi: 10.1136/jmedgenet-2020-107095. Epub 2020 Sep 11. J Med Genet. 2021. PMID: 32917770 Free PMC article.
METHODS: Here, we identify spatial-regulatory connections with potential to regulate expression of cohesin loci (Mitotic: SMC1A, SMC3, STAG1, STAG2, RAD21/RAD21-AS; Meiotic: SMC1B, STAG3, REC8, RAD21L1), cohesin-ring support genes (NIPBL, MAU2, WAPL, PDS5A, PDS5B) a …
METHODS: Here, we identify spatial-regulatory connections with potential to regulate expression of cohesin loci (Mitotic: SMC1A, SMC3, STAG1 …
Synthetic Lethality between Cohesin and WNT Signaling Pathways in Diverse Cancer Contexts.
Pallotta MM, Di Nardo M, Musio A. Pallotta MM, et al. Cells. 2024 Mar 30;13(7):608. doi: 10.3390/cells13070608. Cells. 2024. PMID: 38607047 Free PMC article.
Synthetic lethality has been suggested as an approach to exploit genetic differences in cancer cells to influence their selective killing. In this study, we show that mutations in ESCO1, NIPBL, PDS5B, RAD21, SMC1A, SMC3, STAG2, and WAPL genes are synthetically letha …
Synthetic lethality has been suggested as an approach to exploit genetic differences in cancer cells to influence their selective killing. I …
Cohesin gene mutations in tumorigenesis: from discovery to clinical significance.
Solomon DA, Kim JS, Waldman T. Solomon DA, et al. BMB Rep. 2014 Jun;47(6):299-310. doi: 10.5483/bmbrep.2014.47.6.092. BMB Rep. 2014. PMID: 24856830 Free PMC article. Review.
Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible for the cohesion of sister chromatids following DNA replication until its cleavage during mitosis thereby enabling faithful segregation of …
Cohesin is a multi-protein complex composed of four core subunits (SMC1A, SMC3, RAD21, and either STAG1 or STAG2) that is responsible …